Found 615 results, showing the newest relevant preprints. Sort by relevancy only.Update me on new preprints

Predicting master transcription factors from pan-cancer expression data

Addiction to these factors was confirmed in studies using THZ1 to inhibit transcription in HGSOC cells, suggesting early down-regulation of these genes may be responsible for cytotoxic effects of THZ1 on HGSOC models. Expand abstract.
3 days ago
10/10 relevant
bioRxiv

A Systems Approach Identifies Enhancer of Zeste Homolog 2 (EZH2) as a Protective Factor in Epilepsy

Identifying the driving transcription factors/cofactors is a non-trivial problem and a limiting step in the understanding of neurological disorders. Expand abstract.
6 days ago
4/10 relevant
bioRxiv

mRNA decapping machinery targets transcripts of the LBD3/ASL9 transcription factor to authorize formation of apical hook and lateral roots in Arabidopsis

Moreover, mutations in the cytokinin transcription factors type-B ARABIDOPSIS RESPONSE REGULATORS (B-ARRs) ARR10 and ARR12 restore these developmental defects of ASL9 overexpression. Expand abstract.
7 days ago
10/10 relevant
bioRxiv

NF1 regulates mesenchymal glioblastoma plasticity and aggressiveness through the AP-1 transcription factor FOSL1

Using transcriptomic data of patient-derived brain tumor stem cell lines (BTSCs), classified based on GBM-intrinsic signatures, we identify the AP-1 transcription factor FOSL1 as a master regulator of the mesenchymal (MES) subtype. Expand abstract.
8 days ago
7/10 relevant
bioRxiv

Dynamic neurotransmitter specific transcription factor expression profiles during Drosophila development

Some transcription factors show a similar profile across development, others only show enrichment or depletion at specific developmental stages. Expand abstract.
10 days ago
10/10 relevant
bioRxiv

Mathematical modeling of plant cell fate transitions controlled by hormonal signals

The model is tested by simulating perturbations in the level of key transcription factors that maintain SAM homeostasis . Expand abstract.
11 days ago
5/10 relevant
bioRxiv

ER stress drives ER-to-Golgi trafficking of ATF6 by blocking its membrane insertion

Therefore, we propose an alternative, sensing-by-synthesis model, in which transcription factors are continuously synthesized, and perturbations to the ER environment are quantitatively sensed by the fraction of sensors that fail to be properly incorporated into ER membrane and sorted to Golgi for activation. Expand abstract.
14 days ago
4/10 relevant
bioRxiv

PHYTOCHROME INTERACTING FACTORs trigger environmentally responsive chromatin dynamics

However, the functional relationship between PIF transcription factors and H2A. Expand abstract.
14 days ago
4/10 relevant
bioRxiv

Degradation of non-coding RNAs promotes recycling of termination factors at sites of transcription

In exosome mutants, these factors are sequestered by ncRNAs and cannot be efficiently recycled to sites of transcription, which induces termination defects genome-wide. ncRNA-dependent, genome-wide termination defects can be recapitulated by the expression of a degradation-resistant, circular RNA containing a natural... Expand abstract.
16 days ago
4/10 relevant
bioRxiv

Genome-wide Analysis In Response to N and C Identifies New Regulators for root AtNRT2 Transporters

Functional analysis of mutants combined with yeast one hybrid experiments confirmed that all 3 transcription factors are regulators of NRT2.4 or NRT2.5 in response to N or C signals. Expand abstract.
16 days ago
4/10 relevant
bioRxiv