Found 594 results, showing the newest relevant preprints. Sort by relevancy only.Update me on new preprints

Therapeutic efficacy of an immune stimulatory gene therapy strategy in a mouse model of high grade brainstem glioma

Adenoviral delivery of TK/Flt3L in mice bearing brainstem gliomas resulted in anti-tumor immunity, recruitment of anti-tumor specific T cells and increased median survival. Expand abstract.
4 days ago
4/10 relevant
bioRxiv

Quantitative analysis of how Myc controls T cell proteomes and metabolic pathways during T cell activation

The data identify both Myc dependent and independent metabolic processes in immune activated T cells. Expand abstract.
5 days ago
10/10 relevant
bioRxiv

Single cell multiomic analysis of T cell exhaustion in vitro

In this study, we demonstrate the power of a single-cell multiomic approach to comprehensively characterize T cells and to precisely monitor changes in differentiation, activation and exhaustion signatures in response to different activation protocols. Expand abstract.
6 days ago
10/10 relevant
bioRxiv

Effective Combination Immunotherapy using Oncolytic Viruses to Deliver CAR Targets to Solid Tumors

CAR T cell-mediated tumor killing also promoted release of virus from dying tumor cells, which propogated tumor expression of CD19t. Expand abstract.
6 days ago
8/10 relevant
bioRxiv

Lipid-mediated insertion of Toll-like receptor (TLR) ligands for facile immune cell engineering

Depoted ligands provide a persistent yet non-permanent adjuvant signal to immune cells that may minimize the intensity and duration of toxicities compared to permanent genetic delivery. Expand abstract.
6 days ago
7/10 relevant
bioRxiv

Long-term absence of Langerhans cells alters the gene expression profile of keratinocytes and dendritic epidermal T cells

Thus, immune cells might play an active role in maintaining tissue homeostasis, which should be taken in consideration at data interpretation. Expand abstract.
7 days ago
10/10 relevant
bioRxiv

An allosteric hot-spot in the tandem-SH2 domain of ZAP-70 regulates T-cell signaling

The proposed mechanism of allosteric coupling is unique to ZAP-70, which is fundamentally different from Syk, a close homolog of ZAP-70 expressed in B-cells. Expand abstract.
7 days ago
8/10 relevant
bioRxiv

Repurposing disulfiram (Tetraethylthiuram Disulfide) as a potential drug candidate against Borrelia burgdorferi in vitro and in vivo

Mechanistically, cellular analysis of lymph nodes revealed a decrease in percentage of CD19+ B cells and increase in total percentage of CD3+ T cells, CD3+ CD4+ T helpers, and naive and effector memory cells in disulfiram-treated mice. Expand abstract.
7 days ago
4/10 relevant
bioRxiv

IRIS: Big data-informed discovery of cancer immunotherapy targets arising from pre-mRNA alternative splicing

Applying IRIS to RNA-Seq data from 22 glioblastomas resected from patients, we identified candidate epitopes and validated their recognition by patient T cells, demonstrating IRIS's utility for expanding targeted cancer immunotherapy. Expand abstract.
8 days ago
7/10 relevant
bioRxiv

The size of $t$-cores and hook lengths of random cells in random partitions

Fix $t \geq 2$. We first give an asymptotic formula for certain sums of the number of $t$-cores. Expand abstract.
14 days ago
4/10 relevant
arXiv