Found 486 results, showing the newest relevant preprints. Sort by relevancy only.Update me on new preprints

Mitochondria define intestinal stem cell differentiation downstream of a FOXO/Notch axis

Importantly, we show that FOXO and Notch signalling converge onto regulation of mitochondrial fission, which in turn provokes stem cell differentiation into the secretory types; Goblet cells and PCs. Expand abstract.
4 days ago
8/10 relevant
bioRxiv

Machine learning-assisted neurotoxicity prediction in human midbrain organoids

In the recent years, brain organoids derived from human induced pluripotent stem cells have risen as novel tools to study neurodegenerative diseases such as Parkinson's disease (PD). Expand abstract.
4 days ago
4/10 relevant
bioRxiv

Single-cell atlas of major haematopoietic tissues sheds light on blood cell formation from embryonic endothelium

Interestingly, AGM is the only one generating haematopoietic stem cells (HSCs). Expand abstract.
4 days ago
4/10 relevant
bioRxiv

Yap1-driven intestinal repair is controlled by group 3 innate lymphoid cells

Our findings reveal that ILC3-driven intestinal repair entails distinct transcriptional networks to control stem cell maintenance and epithelial regeneration which implies that tissue repair and crypt proliferation can be influenced by targeting innate immune cells independent of the well-established... Expand abstract.
7 days ago
7/10 relevant
bioRxiv

Nuclear gene proximity and protein interactions shape transcript covariances in mammalian single cells

We apply a tailored experimental design that eliminates these confounders, and report80,000 intrinsically covarying gene pairs in mouse embryonic stem cells. Expand abstract.
8 days ago
5/10 relevant
bioRxiv

Remodeling of the H3 nucleosomal landscape during mouse aging

Here, we report the analysis of genome-wide profiles of core histone H3 occupancy in aging male mice tissues (i.e. heart, liver, cerebellum and olfactory bulb) and primary cultures of neural stem cells. Expand abstract.
9 days ago
4/10 relevant
bioRxiv

StemBond hydrogels optimise the mechanical microenvironment for embryonic stem cells

We show that soft StemBond hydrogels provide an optimal format for culturing embryonic stem (ES) cells. Expand abstract.
10 days ago
10/10 relevant
bioRxiv

Xmas ESC: A new female embryonic stem cell system that reveals the BAF complex as a key regulator of the establishment of X chromosome inactivation

Although female pluripotency significantly differs to male, complications with in vitro culture of female embryonic stem cells (ESC) have severely limited the use and study of these cells. Expand abstract.
11 days ago
9/10 relevant
bioRxiv

Computational model combined with in vitro experiments to analyse mechanotransduction during mesenchymal stem cell adhesion

In the present study, the mechanical signals involved in cell adhesion were computed in in vitro stem cells of different shapes using a single cell model, the so-called Cytoskeleton Divided Medium (CDM) model. Expand abstract.
11 days ago
10/10 relevant
arXiv

Targeting the Id1-Kif11-Aurka axis in triple negative breast cancer using combination therapy

Evidence points to breast cancer following a hierarchical model, with Cancer Stem Cells (CSCs) driving critical phenotypes of the bulk tumor. Expand abstract.
12 days ago
4/10 relevant
bioRxiv