Found 1273 results, showing the newest relevant preprints. Sort by relevancy only.Update me on new preprints

ROGUE: an entropy-based universal metric for assessing the purity of single cell population

ROGUE can be applied to all tested scRNA-seq datasets, and has important implications for evaluating the quality of putative clusters, discovering pure cell subtypes and constructing comprehensive, detailed and standardized single cell atlas. Expand abstract.
47 days ago
10/10 relevant
bioRxiv

Deformability based sorting of stored red blood cells reveals donor-dependent aging curves

Microfluidic technologies have enabled single cell measurement of RBC deformation but have not been able to consistently distinguish differences between RBCs between healthy donors. Expand abstract.
49 days ago
4/10 relevant
bioRxiv

Machine Learning Approaches Identify Genes Containing Spatial Information from Single-Cell Transcriptomics Data.

Availability: https://github.com/TJU-CMC-Org/SingleCell-DREAM/. Expand abstract.
49 days ago
10/10 relevant
bioRxiv

Single-cell dissection of a rare human prostate basal cell carcinoma

Interestingly, at single-cell resolution the gene expression patterns of prostate BCC tumor cells show uniqueness compared with that of common prostate cancer-derived circulating tumor cells. Expand abstract.
49 days ago
10/10 relevant
bioRxiv

Generation and Trapping of a Mesoderm Biased State of Human Pluripotency

The use of "cross-antagonistic" signalling to trap pluripotent stem cell intermediates with different lineage-bias may have general applicability in the efficient production of cells for regenerative medicine. Expand abstract.
49 days ago
5/10 relevant
bioRxiv

Single-cell sequencing of mouse thymocytes reveals mutational landscape shaped by replication errors, mismatch repair and H3K36me3

To dissect how replication errors, abundance of H3K36me3 and MMR together shape the mutational landscape in normal mammalian cells, we applied single-cell exome sequencing to thymic T cells isolated from MMR-proficient (Mlh1+/+) and MMR-deficient (Mlh1-/-) mice. Expand abstract.
49 days ago
10/10 relevant
bioRxiv

CTRL: a label-free method for dynamic measurement of single-cell volume

Current single-cell volume measurement methods for mammalian cells are labor-intensive, inflexible, and can cause cell damage. Expand abstract.
49 days ago
10/10 relevant
bioRxiv

Analysis of single-cell gene pair coexpression landscapes by stochastic kinetic modeling reveals gene-pair interactions in development

We applied the theoretical results to analysis of published single cell RNA sequencing data and uncovered complex dynamics of coexpression among gene pairs during embryonic development. Expand abstract.
51 days ago
10/10 relevant
bioRxiv

Test-time augmentation for deep learning-based cell segmentation on microscopy images

In this paper we describe incorporating the test-time argumentation prediction method into two major segmentation approaches used in the single-cell analysis of microscopy images, namely semantic segmentation using U-Net and instance segmentation using Mask R-CNN models. Expand abstract.
51 days ago
4/10 relevant
bioRxiv

A Versatile Polypharmacology Platform Promotes Cytoprotection and Viability of Human Pluripotent and Differentiated Cells

In proof-of-principle experiments we then demonstrated the strong improvements that CEPT provided for several key applications in stem cell research, including routine cell passaging, cryopreservation of pluripotent and differentiated cells, embryoid body and organoid formation, single-cell cloning,... Expand abstract.
52 days ago
4/10 relevant
bioRxiv