Found 892 results, showing the newest relevant preprints. Sort by relevancy only.Update me on new preprints

scClassify: hierarchical classification of cells

To capitalize on the large collections of well-annotated scRNAseq datasets, we present scClassify, a hierarchical classification framework based on ensemble learning. scClassify can identify cells from published scRNAseq datasets more accurately and more finely than in the original publications. Expand abstract.
1 hours ago
4/10 relevant
bioRxiv

Dinoroseobacter shibae outer membrane vesicles are enriched for the chromosome dimer resolution site dif

Single cell analysis using time-lapse microscopy showed that individual cells secreted multiple OMVs, preferentially at the septum during cell division. Expand abstract.
3 days ago
5/10 relevant
bioRxiv

Dynamic analysis of pulsed cisplatin identifies effectors of resistance in lung adenocarcinoma

By coupling this data with real-time, single cell imaging of cell cycle and apoptosis, we show that TP53 mutation status influenced the mode of cisplatin induced cell cycle arrest, but could not predict cisplatin sensitivity. Expand abstract.
3 days ago
4/10 relevant
bioRxiv

Gravity-based microfiltration reveals unexpected prevalence of circulating tumor cell clusters in ovarian cancer

Circulating tumor cells (CTCs) are rare (few cells per milliliter of blood) and mostly isolated as single cell CTCs (scCTCs). Expand abstract.
4 days ago
7/10 relevant
bioRxiv

Single-cell atlas of major haematopoietic tissues sheds light on blood cell formation from embryonic endothelium

Our results indicate that the AGM is a tissue more favourable to HSCs development than the YS because of its microenvironment and the nature of its endothelial cells. Expand abstract.
4 days ago
10/10 relevant
bioRxiv

Autoencoder-based cluster ensembles for single-cell RNA-seq data analysis

Background: Single-cell RNA-sequencing (scRNA-seq) is a transformative technology, allowing global transcriptomes of individual cells to be profiled with high accuracy. Expand abstract.
4 days ago
10/10 relevant
bioRxiv

scHiCTools: a computational toolbox for analyzing single cell Hi-C data

Here, we present an open source computational toolbox, scHiCTools, which provides three commonly used methods for smoothing scHi-C data (linear convolution, random walk, and network enhancing) and three projection methods for embedding single cells into a lower dimensional Euclidean space (fastHiCRep, Selfish, and... Expand abstract.
5 days ago
10/10 relevant
bioRxiv

Epigenetic adaptation prolongs photoreceptor survival during retinal degeneration

Our study reveals an intrinsic mechanism by which neural cells progressively adapt to genetic stress to achieve prolonged survival through epigenomic regulation and chromatin state modulation. Expand abstract.
6 days ago
7/10 relevant
bioRxiv

I-Impute: a self-consistent method to impute single cell RNA sequencing data

Furthermore, we collected three wetlab datasets, mouse bladder cells dataset, embryonic stem cells dataset, and aortic leukocyte cells dataset, to evaluate the tools. Expand abstract.
6 days ago
10/10 relevant
bioRxiv

In silico stress fibre content affects peak strain in cytoplasm and nucleus but not in membrane for uniaxial substrate stretch

Existing in silico models for single cells feature limited representations of cytoskeletal structures that present inhomogeneities in the cytoplasm and contribute substantially to the mechanical behaviour of the cell. Expand abstract.
6 days ago
7/10 relevant
bioRxiv