TDP-43 α-helical structure tunes liquid-**liquid** phase separation and function

**liquid**phase separation (LLPS) is involved in the formation of membraneless organelles (MLOs) associated with RNA processing. Expand abstract.

**Liquid**-

**liquid**phase separation (LLPS) is involved in the formation of membraneless organelles (MLOs) associated with RNA processing. Present in several MLOs, TDP-43 undergoes LLPS and is linked to the pathogenesis of amyotrophic lateral sclerosis (ALS). While some disease variants of TDP-43 disrupt self-interaction and function, here we show that designed single mutations can enhance TDP-43 assembly and function via modulating helical structure. Using molecular simulation and NMR spectroscopy, we observe large structural changes in a dimeric TDP-43. Two conserved glycine residues (G335 and G338) are potent inhibitors of helical extension and helix-helix interaction, which are removed in part by variants including the ALS-associated G335D. Substitution to helix-enhancing alanine at either of these positions dramatically enhances phase separation in vitro and decreases fluidity of phase separated TDP-43 reporter compartments in cells. Furthermore, G335A increases TDP-43 splicing function in a mini-gene assay. Therefore, TDP-43 helical region serves as a short but uniquely tunable module that shows promise as for controlling assembly and function in cellular and synthetic biology applications of LLPS.

10/10 relevant

bioRxiv

Topological thermal Hall effect of "magnetic monopoles" in pyrochlore
U(1) spin **liquid**

**liquid**candidate materials. Expand abstract.

**liquid**. Our result does not depend strongly on our choice of non-Kramers doublets for our presentation, and can be well extended to Kramers doublets. Our prediction can be readily tested among the pyrochlore spin

**liquid**candidate materials. We give a detailed discussion about the expectation for different pyrochlore magnets.

4/10 relevant

arXiv

Wetting boundaries for ternary high density ratio Lattice Boltzmann Method

**liquid**or liquid-gas interfaces. Expand abstract.

**liquid**displacing the gas phase, and the self-propelled motion of a train of drops. Furthermore, we measure dynamic angles and show that the slip length critically depends on the equilibrium value of the contact angles, and whether it belongs to

**liquid**-

**liquid**or

**liquid**-gas interfaces. These results validate the model capabilities of simulating complex ternary fluid dynamic problems near solid boundaries, for example drop impact solid substrates covered by a lubricant layer.

4/10 relevant

arXiv

Classical and quantum **liquids** induced by quantum fluctuations

**liquids**can emerge from their classical counterparts. Expand abstract.

**liquids**and how the degeneracy is affected by quantum fluctuations is, however, less well understood. We study a simple model of coupled quantum and classical degrees of freedom, the so-called Falicov-Kimball model, on a triangular lattice and away from half-filling. For weak interactions the phase diagram features a charge disordered state down to zero temperature. We provide compelling evidence that this phase is a

**liquid**and show that it is divided by a crossover line that terminates in a quantum critical point. Our results offer a new vantage point to address how quantum

**liquids**can emerge from their classical counterparts.

4/10 relevant

arXiv

SU(4) topological RVB spin **liquid** on the square lattice

**liquid**. Evidence for the topological nature of this spin

**liquid**is provided by the investigation of the Renyi entanglement entropy of infinitely-long cylinders and of the modular matrices. Relevance to microscopic models and experiments of ultracold atoms is discussed.

4/10 relevant

arXiv

Steady streaming flows in viscoelastic **liquids**

**liquids**with strong shear thinning, however, display two unique features: (i) a non-monotonic evolution of the inner streaming layer with increasing frequency, first growing then decreasing in width, and (ii) a clear asymmetry in the flow profile at high frequencies. Expand abstract.

**liquids**are qualitatively similar to those in Newtonian

**liquids**. Steady streaming velocity profiles in elastic

**liquids**with strong shear thinning, however, display two unique features: (i) a non-monotonic evolution of the inner streaming layer with increasing frequency, first growing then decreasing in width, and (ii) a clear asymmetry in the flow profile at high frequencies.

4/10 relevant

arXiv

Finite element simulation of the liquid-**liquid** transition to metallic
hydrogen

**liquid**molecular phase to a conductive atomic state, or

**liquid**metallic hydrogen, sometimes referred to as the plasma phase transition (PPT). The PPT phase line was observed in a recent experiment studying laser-pulse heated hydrogen in a diamond anvil cell in the pressure range $\sim 100 - 170 \text{GPa}$ for temperatures up to $\sim 2000 \text{K}$. The experimental signatures of the transition are (i) a negative pressure-temperature slope, (ii) a plateau in the heating curve, assumed to be related to the latent heat of transformation, and (iii) an abrupt increase in the reflectance of the sample. We present a finite element simulation that accurately takes into account the position and time dependence of the heat deposited by the laser pulse. We calculate the heating curves and the sample reflectance and transmittance. This simulation confirms that the observed plateaus are related to the phase transition, however we find that large values of latent heat are needed and may indicate that dynamics at the transition are more complex than considered in current models. Finally, experiments are proposed that can distinguish between a change in optical properties due to a transition to a metallic state or due to closure of the bandgap in molecular hydrogen.

8/10 relevant

arXiv

Benchmarking vdW-DF first principle predictions against Coupled
Electron-Ion Monte Carlo for high pressure **liquid** hydrogen

**liquid**phase transition is observed with both theories in the same density region but the one predicted by vdW has a smaller density discontinuity, i.e. a smaller first order character. Expand abstract.

**liquid**hydrogen along two isotherms in the region of molecular dissociation. We employ Density Functional Theory with the vdW-DF approximation (vdW) and we benchmark the results against existing predictions from Coupling Electron-Ion Monte Carlo (CEIMC). At fixed density and temperature, we find that pressure from vdW is higher than pressure from CEIMC by about 10 GPa in the molecular insulating phase and about 20 GPa in the dissociated metallic phase. Molecules are found to be overstabilized using vdW, with a slightly shorter bond length, and with a stronger resistance to compression. As a consequence, pressure dissociation along isotherms using vdW is more progressive than computed with CEIMC. Below the critical point, the

**liquid**-

**liquid**phase transition is observed with both theories in the same density region but the one predicted by vdW has a smaller density discontinuity, i.e. a smaller first order character. The optical conductivity computed using Kubo-Greenwood is rather similar for the two systems and reflects the slightly more pronounced molecular character of vdW.

5/10 relevant

arXiv

Correlated spin **liquids** in the quantum kagome antiferromagnet at finite
field: a renormalisation group analysis

**liquid**phases whose position is determined as a function of the exchange anisotropy and the energy scale for fluctuations arising from spinon scattering. Two of these spins

**liquids**are topologically ordered states of matter with gapped, degenerate states on the torus. The gap for one of these phases corresponds to the one-spinon band gap of the Azbel-Hofstadter spectrum for the XY part of the Hamiltonian, while the other arises from two-spinon interactions. The Heisenberg point of this problem is found to lie within the interaction gapped spin

**liquid**phase, in broad agreement with a recent experimental finding. The third phase is an algebraic spin

**liquid**with a gapless Dirac spectrum for spinon excitations, and possess properties that show departures from the Fermi

**liquid**paradigm. The three phase boundaries correspond to critical theories, and meet at a $SU(2)$-symmetric multicritical point. This special critical point agrees well with the gap-closing transition point predicted by Kumar \emph{et al}. We discuss the relevance of our findings to various recent experiments, as well as results obtained from other theoretical analyses.

4/10 relevant

arXiv

Quantum spin **liquid** at finite temperature: proximate dynamics and
persistent typicality

**liquids**are long-range entangled states of matter with emergent gauge fields and fractionalized excitations. While candidate materials, such as the Kitaev honeycomb ruthenate $\alpha$-RuCl$_3$, show magnetic order at low temperatures $T$, here we demonstrate numerically a dynamical crossover from magnon-like behavior at low $T$ and frequencies $\omega$ to long-lived fractionalized fermionic quasiparticles at higher $T$ and $\omega$. This crossover is akin to the presence of spinon continua in quasi-1D spin chains. It is further shown to go hand in hand with persistent typicality down to very low $T$. This aspect, which has also been observed in the spin-1/2 kagome Heisenberg antiferromagnet, is a signature of proximate spin liquidity and emergent gauge degrees of freedom more generally, and can be the basis for the numerical study of many finite-$T$ properties of putative spin

**liquids**.

4/10 relevant

arXiv