Found 10439 results, showing the newest relevant preprints. Sort by relevancy only.Update me on new preprints

Ru-Catalyzed Carbonylative Murai Reaction: Directed C3-Acylation of Biomass-Derived 2-Formyl Heteroaromatics

DFT computations of the full catalytic cycle help in deciphering the mechanism of this transformation, and to rationalize the different behaviors depending on the nature of imine directing groups. Expand abstract.
18279 days ago
4/10 relevant
chemRxiv

Dithiasuccinoyl-Caged Amines Enables COS/H2S Release Lacking Electrophilic Byproducts

As a mild alternative, we demonstrate here that dithiasuccinoyl groups can function as COS/H2S donor motifs and that these groups release two equivalents of COS/H2S and uncage an amine payload under physiologically relevant conditions. Expand abstract.
18279 days ago
4/10 relevant
chemRxiv

CO2 Solubility in Organophosphate Physical Solvents Wherein Alkyl Groups Are Replaced with Poly(Ethylene Glycol) Groups

Although introducing PEG groups to these molecules increased the number of interaction sites with CO2, solvents (1) – (3) showed poorer CO2 absorption than TBP and TiBP due to their decreased solvent fractional free volume. Expand abstract.
18279 days ago
7/10 relevant
chemRxiv

Novel Protective Group Synthesis of Androgen Receptor Modulators with Steroidal and Nonsteroidal Scaffolds

In order to obtain androgen receptor modulating compounds of high purity for mechanistic in vitro investigations, this study summarizes protocols of optimized chemical synthesis for five AAS and two SARMs. Expand abstract.
18279 days ago
5/10 relevant
chemRxiv

Ester Dance Reaction on the Aromatic Ring

Herein, we describe an unprecedented “ester dance” reaction: a predictable translocation of an ester group from one carbon atom to another on an aromatic ring. Expand abstract.
18279 days ago
4/10 relevant
chemRxiv

(2-Hydroxy-4-methoxy)benzyl Aminoadamantane Conjugates as Probes to Investigate Specificity Determinants in Blocking Influenza M2 S31N and M2 WT Channels with Binding Kinetics and Simulations

The low kon values can be interpreted from MD simulations, which suggest distortions to V27 cluster of the M2 S31N caused by the longer (even by one methylene) hydrophobic segment from adamantane to aryl head group, appropriate to fit from G34 to V27. Expand abstract.
18279 days ago
4/10 relevant
chemRxiv

Imine as a Linchpin Approach for Distal C(sp2)–H Functionalization

Application of this transient directing group strategy for streamlining the synthesis of complex organic molecules without any necessary pre-functionalization at the distal position has been explored. Expand abstract.
18279 days ago
4/10 relevant
chemRxiv

On the Adsorption of Aspartate Derivatives to Calcite Surfaces in Aqueous Environment

Moreover, while attachment of the negatively charged carboxylate groups is also frequently observed, it is always balanced by the aqueous solvation of an equal or greater number of carboxylates. Expand abstract.
18279 days ago
4/10 relevant
chemRxiv

“Unhappiness is my lot”. Or is it? Depression in students who perform or study music as compared to students who do not.

The depression factors of anxiety and pain processing were lower in both musicians’ groups compared to non-music students, despite the latter group perceiving pain for shorter periods of time than all musicians. Expand abstract.
7 hours ago
5/10 relevant
PsyArXiv

Impact of Periampullary Diverticulum on Biliary Cannulation and ERCP Outcomes: A Single-Center Prospective Study

Methods: A total of 636 patients who underwent endoscopic retrograde cholangiopancreatography (ERCP) during the study period were prospectively studied and divided into two groups based on the presence or absence of PAD. Expand abstract.
14 hours ago
6/10 relevant
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