Found 1735 results, showing the newest relevant preprints. Sort by relevancy only.Update me on new preprints

Fat food exacerbates post-prandial hypothalamic inflammation involving GFAP+ cells and microglia

This remodeling was associated with higher expression of inflammatory genes and differential activation of hypothalamic neuropeptides involved in energy balance regulation. Expand abstract.
28 days ago
4/10 relevant
bioRxiv

Predicting master transcription factors from pan-cancer expression data

Addiction to these factors was confirmed in studies using THZ1 to inhibit transcription in HGSOC cells, suggesting early down-regulation of these genes may be responsible for cytotoxic effects of THZ1 on HGSOC models. Expand abstract.
28 days ago
5/10 relevant
bioRxiv

Synthetic gene regulatory networks in the opportunistic human pathogen Streptococcus pneumoniae

The tools described here can be used to mimic complex expression patterns, such as the ones found for pneumococcal virulence factors, paving the way for in vivo investigations of the importance of gene expression control on the pathogenicity of S. pneumoniae. Expand abstract.
29 days ago
6/10 relevant
bioRxiv

SpaCell: integrating tissue morphology and spatial gene expression to predict disease cells

We developed a user-friendly deep learning software, SpaCell, to integrate millions of pixel intensity values with thousands of gene expression measurements from spatially-barcoded spots in a tissue. Expand abstract.
30 days ago
10/10 relevant
bioRxiv

Semaphorin 3a reduces the side effects of radiation on BMSCs by reducing ROS

Real-time PCR was performed to test the expression of osteogenic (osteocalcin and Runt-related transcription factor 2), adipogenic (peroxisome proliferator-activated receptor gamma), interleukin (IL)-6, and tumor necrosis factor (TNF)- genes. Expand abstract.
30 days ago
4/10 relevant
bioRxiv

Direct readout of neural stem cell transgenesis with an integration-coupled gene expression switch

These results establish iOn as an efficient and widely applicable strategy to report transgenesis and accelerate genetic engineering in cultured systems and model organisms. Expand abstract.
32 days ago
8/10 relevant
bioRxiv

The Hippo pathway oncoprotein YAP promotes melanoma cell invasion and spontaneous metastasis

Finally, we identified the YAP target genes AXL, THBS1 and CYR61 as key mediators of YAP-induced melanoma cell invasion. Expand abstract.
32 days ago
4/10 relevant
bioRxiv

Transcriptomics of Type 2 Diabetic and Healthy Human Neutrophils

Results: We observed significant differential expression of 50 genes between T2D and healthy neutrophils (p Expand abstract.
32 days ago
4/10 relevant
medRxiv

Leaderless short ORFs in mycobacteria comprise a translational regulon

Through detailed mutational analysis, we show that one such polycysteine-encoding short ORF controls expression of the downstream genes by causing ribosome stalling under conditions of low cysteine. Expand abstract.
33 days ago
4/10 relevant
bioRxiv

Transcriptome-wide transmission disequilibrium analysis identifies novel risk genes for autism spectrum disorder

These results provide a clear example of the connection between ASD genes affected by very rare mutations and an unlinked key regulator affected by common genetic variations. Expand abstract.
33 days ago
4/10 relevant
bioRxiv