Found 1751 results, showing the newest relevant preprints. Sort by relevancy only.Update me on new preprints

A Hierarchical Machine Learning Model to Discover Gleason Grade Group-specific Biomarkers in Prostate Cancer

A hierarchical model with standard classifiers in different Gleason groups (hereinafter called nodes) to identify and predict nodes based on their mRNA or gene expressions. Expand abstract.
18 days ago
9/10 relevant
Preprints.org

Comparative transcriptomics reveals domestication-associated features of Atlantic salmon lipid metabolism

Domesticated salmon had lower expression of cry2 and nr1d1, genes involved in negative regulation of circadian rhythm, with possible implications for the diurnal cycle of feed ingestion and basal metabolic rate. Expand abstract.
19 days ago
4/10 relevant
bioRxiv

Odd-paired is a late-acting pioneer factor coordinating with Zelda to broadly regulate gene expression in early embryos

Odd-paired (Opa), a zinc-finger transcription factor expressed at cellularization, controls transition of genes from pair-rule to segmental patterns along the anterior-posterior axis. Expand abstract.
19 days ago
10/10 relevant
bioRxiv

Approaching Small Molecule Prioritization as a Cross-Modal Information Retrieval Task through Coordinated Representation Learning

We then test this approach by using held-out gene expression signatures as queries into embedding space to recover their corresponding compounds. Expand abstract.
20 days ago
4/10 relevant
arXiv

Ctcf Haploinsufficiency Mediates Intron Retention in A Tissue-specific Manner

This study provides further evidence for Ctcf dose-dependent and tissue-specific regulation of gene expression and AS. Expand abstract.
20 days ago
6/10 relevant
bioRxiv

Time-of-day dependent responses of cyanobacterial cellular viability against oxidative stress

The gene expression of ROS scavenging enzymes is regulated by circadian clock genes, which has been considered to help deal with the diurnal photogeneration of reactive oxygen species (ROS). Expand abstract.
20 days ago
4/10 relevant
bioRxiv

Controlling spatiotemporal pattern formation in a concentration gradient with a synthetic toggle switch

The toggle switch subnetwork, composed of two cross-repressing transcription factors, is a common component of gene regulatory networks in charge of patterning, converting the continuous information provided by the gradient into discrete abutting stripes of gene expression. Expand abstract.
21 days ago
5/10 relevant
bioRxiv

Linking lysosomal enzyme targeting genes and energy metabolism with altered gray matter volume in children with persistent stuttering

Although the results are correlational and cannot inform us about underlying casual mechanisms, our results suggest a possibility that regions with high expression level of genes associated with stuttering may be particularly vulnerable to the effect of alterations in these genes. Expand abstract.
21 days ago
7/10 relevant
bioRxiv

Low iron-induced small RNA BrrF regulates central metabolism and oxidative stress responses in Burkholderia cenocepacia

Phenotypic and gene expression analysis of BrrF deletion and overexpression mutants show that the regulation of these genes is BrrF-dependent. Expand abstract.
22 days ago
5/10 relevant
bioRxiv

Quercetin Exerts Anti-Inflammatory Effects via Meanwhile Suppressing TLR2 Gene Expression and STAT3 Protein Phosphorylation in Activated Inflammatory Macrophages

As a result, Q and its metabolite quercetin-3-O-β-D-glucuronide (Q3G) decreased TNF-α gene expression amounts and ratios of pro-/anti-inflammatory (TNF-α/IL-10) cytokine gene expressions, but increased IL-10 gene expression amounts in activated inflammatory macrophages, supporting a... Expand abstract.
22 days ago
10/10 relevant
Preprints.org