Found 1751 results, showing the newest relevant preprints. Sort by relevancy only.Update me on new preprints

Assessing Environmental RNAi in a Non-Model Organism

This suggests spider mite RNAi pathway products that originate as ingested materials may be preferentially metabolized instead of converted into regulators of gene expression. Expand abstract.
12 days ago
5/10 relevant
bioRxiv

Cardiac Hypertrophy in a Dish: A Human Stem Cell Based Model

Moreover, transcriptional profiling using RNA-sequencing was performed to identify differentially expressed genes following ET-1 stimulation. Expand abstract.
12 days ago
4/10 relevant
Preprints.org

Supervised and Unsupervised End-to-End Deep Learning for Gene Ontology Classification of Neural In Situ Hybridization Images

Traditional image processing methods are typically applied for learning functional representations of genes, based on their expressions in these brain images. Expand abstract.
13 days ago
4/10 relevant
arXiv

Alignment of time-course single-cell RNA-seq data with CAPITAL

Computational tests on time-series public data indicate that CAPITAL can align non-linear pseudotime trajectories and reveal gene expression dynamics. Expand abstract.
13 days ago
4/10 relevant
bioRxiv

Interplay between TERT promoter mutations and methylation culminates in chromatin accessibility and TERT expression

This study aimed to elucidate the combined contribution of epigenetic (promoter methylation and higher-order chromatin structure) and genetic (promoter mutations) mechanisms in regulating TERT gene expression in healthy skin and in melanoma cell lines (n=61). Expand abstract.
14 days ago
5/10 relevant
bioRxiv

Microscale Collagen and Fibroblast Interactions Enhance Primary Human Hepatocyte Functions in 3-Dimensional Models

Additionally, the 3T3-J2-coated PHH microtissues displayed 6+ weeks of relatively stable hepatic gene expression and function at levels similar to freshly thawed PHHs. Expand abstract.
14 days ago
5/10 relevant
bioRxiv

CCLA: an accurate method and web server for cancer cell line authentication using gene expression profiles

Users can freely and conveniently authenticate CCLs using gene expression profiles or NCBI GEO accession on CCLA website. Expand abstract.
14 days ago
10/10 relevant
bioRxiv

The Role of Scale in the Estimation of Cell-type Proportions

Using log-scale gene expressions proposes a biologically implausible model and using linear-scale gene expressions will lead to statistically inefficient estimators. Expand abstract.
14 days ago
8/10 relevant
bioRxiv

Theoretical properties of nearest-neighbor distance distributions and novel metrics for high dimensional bioinformatics data

In addition to these expressions for continuous data, we derive similar analytical formulas for a new metric for genetic variants (categorical data) in genome-wide association studies (GWAS). Expand abstract.
14 days ago
5/10 relevant
bioRxiv

Single cell analysis of the effects of developmental lead (Pb) exposure on the hippocampus.

Across all cells, differential gene expression analysis by Pb treatment revealed cluster marker genes. Expand abstract.
14 days ago
7/10 relevant
bioRxiv