Found 1974 results, showing the newest relevant preprints. Sort by relevancy only.Update me on new preprints

Transcription closed and open complex formation coordinate expression of genes with a shared promoter region

We find that only in specific regions of the parameter space of the rate-limiting steps is orderly co-expression exhibited, suggesting that successful cooperation between closely spaced genes requires the co-evolution of compatible rate-limiting step configuration. Expand abstract.
73 days ago
5/10 relevant
bioRxiv

Predicting the carbon source for Bacillus subtilis by integrating gene expression profiles into a constraint-based metabolic model

We present that using FBA model with gene expression data is a good starting point to support subsequent hypotheses to conduct further studies; especially, in the environment that 13C metabolic flux data is hard to achieve. Expand abstract.
74 days ago
5/10 relevant
bioRxiv

WormCat: an online tool for annotation and visualization of Caenorhabditis elegans genome-scale data

To allow categorization and visualization of enriched C. elegans gene sets in different types of genome-scale data, we developed WormCat, a web-based tool that uses a near-complete annotation of the C. elegans genome to identify co-expressed gene sets and scaled heat map for enrichment visualization. Expand abstract.
74 days ago
4/10 relevant
bioRxiv

Integrated Genomic Analysis Reveals Key Features of Long Undecoded Transcript Isoform (LUTI)-based Gene Repression

We conclude that LUTIs downregulate gene expression in a manner that integrates translational repression, chromatin state changes, and the magnitude of LUTI expression. Expand abstract.
74 days ago
5/10 relevant
bioRxiv

XenoCP: Cloud-based BAM cleansing tool for RNA and DNA from Xenograft

We show application of XenoCP in obtaining accurate gene expression quantification in RNA-seq and tumor heterogeneity in WGS of xenografts derived from brain and solid tumors. Expand abstract.
74 days ago
4/10 relevant
bioRxiv

Global reprogramming of virulence and antibiotic resistance in Pseudomonas aeruginosa by a single nucleotide polymorphism in the elongation factor-encoding gene, fusA1.

Through a combination of proteomic and transcriptomic analyses, we found that the fusA1 mutant also exhibited large-scale but discrete changes in the expression of key pathogenicity-associated genes. Expand abstract.
74 days ago
5/10 relevant
bioRxiv

LMSM: a modular approach for identifying lncRNA related miRNA sponge modules in breast cancer

To understand the miRNA sponging activities in biological conditions, LMSM uses gene expression data to evaluate the influence of the shared miRNAs on the clustered sponge lncRNAs and mRNAs. Expand abstract.
74 days ago
4/10 relevant
bioRxiv

Neural Gene Network Constructor: A Neural Based Model for Reconstructing Gene Regulatory Network

Here, we present a deep learning model 'Neural Gene Network Constructor' (NGNC), for inferring gene regulatory network and reconstructing the gene dynamics simultaneously from time series gene expression data. Expand abstract.
75 days ago
5/10 relevant
bioRxiv

Chimpanzee fibroblasts exhibit greater adherence and migratory phenotypes than human fibroblasts

The gene expression data suggest that the enhanced adhesive properties of chimpanzee fibroblasts may be due to chimpanzee fibroblasts exhibiting significantly higher expression of cell and focal adhesion molecule genes than human cells, both during a wound healing assay and at rest. Expand abstract.
75 days ago
6/10 relevant
bioRxiv

Comparative transcriptomics reveal distinct patterns of gene expression conservation through vertebrate embryogenesis

We use an unbiased clustering approach to group stages of embryogenesis by transcriptomic similarity and ask whether gene expression similarity of clustered embryonic stages deviates from the null hypothesis of no relationship between timing and diversification. Expand abstract.
75 days ago
7/10 relevant
bioRxiv