Found 1974 results, showing the newest relevant preprints. Sort by relevancy only.Update me on new preprints

Investigation of the quorum-sensing regulon of the biocontrol bacterium Pseudomonas chlororaphis strain PA23

Inspection of the promoter regions revealed the presence of "phz-box" sequences in only 58 of the 807 differentially expressed genes, suggesting that much of the QS regulon is indirectly regulated. Expand abstract.
63 days ago
4/10 relevant
bioRxiv

Thiamethoxam exposure in honey bees deregulates short ORF gene expression in the brain and compromises the immune response

Unexpectedly, most of these genes have no annotated function, but encode short Open Reading Frames (sORFs), a characteristic feature of anti-microbial peptides. Expand abstract.
63 days ago
10/10 relevant
bioRxiv

Heterologous glycosyl hydrolase expression and cellular reprogramming resembling sucrose-induction enable Zymomonas mobilis growth on cellobiose

Growth on cellobiose was achieved after a prolonged lag phase in cellobiose medium that induced changes in gene expression and cell composition, including increased expression and secretion of GH. Expand abstract.
64 days ago
4/10 relevant
bioRxiv

Single Cell RNA Sequencing Reveals Heterogeneity of Human MSC Chondrogenesis: Lasso Regularized Logistic Regression to Identify Gene and Regulatory Signatures

Using a machine learning technique - lasso regularized logistic regression - we showed that multiple subpopulations of cells existed at all stages during MSC chondrogenesis and were better-defined by transcription factor activity rather than gene expression. Expand abstract.
64 days ago
7/10 relevant
bioRxiv

An Integrative Network-based Analysis Reveals Gene Networks, Biological Mechanisms, and Novel Drug Targets in Alzheimer's Disease

We also performed a computational drug repositioning analysis by integrating gene expression changes within Alzheimer's disease modules with drug-gene signatures from the Connectivity Map, and show disease implicated networks retrieve known Alzheimer's disease drugs and novel drug repurposing candidates for follow-up... Expand abstract.
64 days ago
4/10 relevant
bioRxiv

A Hierarchical Machine Learning Model to Discover Gleason Grade Group-specific Biomarkers in Prostate Cancer

A hierarchical model with standard classifiers in different Gleason groups (hereinafter called nodes) to identify and predict nodes based on their mRNA or gene expressions. Expand abstract.
64 days ago
9/10 relevant
Preprints.org

Comparative transcriptomics reveals domestication-associated features of Atlantic salmon lipid metabolism

Domesticated salmon had lower expression of cry2 and nr1d1, genes involved in negative regulation of circadian rhythm, with possible implications for the diurnal cycle of feed ingestion and basal metabolic rate. Expand abstract.
65 days ago
4/10 relevant
bioRxiv

Odd-paired is a late-acting pioneer factor coordinating with Zelda to broadly regulate gene expression in early embryos

Odd-paired (Opa), a zinc-finger transcription factor expressed at cellularization, controls transition of genes from pair-rule to segmental patterns along the anterior-posterior axis. Expand abstract.
65 days ago
10/10 relevant
bioRxiv

Approaching Small Molecule Prioritization as a Cross-Modal Information Retrieval Task through Coordinated Representation Learning

We then test this approach by using held-out gene expression signatures as queries into embedding space to recover their corresponding compounds. Expand abstract.
66 days ago
4/10 relevant
arXiv

Ctcf Haploinsufficiency Mediates Intron Retention in A Tissue-specific Manner

This study provides further evidence for Ctcf dose-dependent and tissue-specific regulation of gene expression and AS. Expand abstract.
66 days ago
6/10 relevant
bioRxiv