Found 1974 results, showing the newest relevant preprints. Sort by relevancy only.Update me on new preprints

Microscale Collagen and Fibroblast Interactions Enhance Primary Human Hepatocyte Functions in 3-Dimensional Models

Additionally, the 3T3-J2-coated PHH microtissues displayed 6+ weeks of relatively stable hepatic gene expression and function at levels similar to freshly thawed PHHs. Expand abstract.
60 days ago
5/10 relevant
bioRxiv

CCLA: an accurate method and web server for cancer cell line authentication using gene expression profiles

Users can freely and conveniently authenticate CCLs using gene expression profiles or NCBI GEO accession on CCLA website. Expand abstract.
60 days ago
10/10 relevant
bioRxiv

The Role of Scale in the Estimation of Cell-type Proportions

Using log-scale gene expressions proposes a biologically implausible model and using linear-scale gene expressions will lead to statistically inefficient estimators. Expand abstract.
60 days ago
8/10 relevant
bioRxiv

Theoretical properties of nearest-neighbor distance distributions and novel metrics for high dimensional bioinformatics data

In addition to these expressions for continuous data, we derive similar analytical formulas for a new metric for genetic variants (categorical data) in genome-wide association studies (GWAS). Expand abstract.
60 days ago
5/10 relevant
bioRxiv

Single cell analysis of the effects of developmental lead (Pb) exposure on the hippocampus.

Across all cells, differential gene expression analysis by Pb treatment revealed cluster marker genes. Expand abstract.
60 days ago
7/10 relevant
bioRxiv

Zbtb24 binding protects promoter activity by antagonizing DNA methylation in mESCs

Remarkably, we identify a set of genes that is particularly susceptible to Zbtb24 occupancy. Expand abstract.
60 days ago
4/10 relevant
bioRxiv

Rapid Alkalinization Factor (RALF) gene family genomic structure and transcriptional regulation during host-pathogen crosstalk in Fragaria vescaand Fragariax ananassastrawberry

Fragaria x ananassa RALF genes expression inducibility upon infection with C. acutatum or B. cinerea was assessed andshowed that, among fruit expressed RALFgenes, FaRALF3-1was the only one upregulated after fungal infection. Expand abstract.
60 days ago
4/10 relevant
bioRxiv

Systems analyses of key metabolic modules of floral and extrafloral nectaries of cotton

Lastly, nectary gene expression data provided evidence to support de novo synthesis of amino acids detected in the secreted nectars. Expand abstract.
61 days ago
4/10 relevant
bioRxiv

MED19 alters AR occupancy and gene expression in prostate cancer cells, driving MAOA expression and growth under low androgen

Under conditions of androgen deprivation, genes regulated by MED19 and genomic sites occupied by MED19 and AR are enriched for ELK1, a transcription factor that binds the AR N-terminus to promote select AR-target gene expression. Expand abstract.
62 days ago
10/10 relevant
bioRxiv

clustifyr: An R package for automated single-cell RNA sequencing cluster classification

The package leverages external datasets, including gene expression profiles from scRNA-seq, bulk RNA-seq, microarray expression data, and/or signature gene lists, to assign likely cell types. Expand abstract.
62 days ago
4/10 relevant
bioRxiv