Found 1974 results, showing the newest relevant preprints. Sort by relevancy only.Update me on new preprints

Hydroxamic Acid-Modified Peptide Microarrays for Profiling Isozyme-Selective Interactions and Inhibition of Histone Deacetylases

Histones control gene expression by regulating chromatin structure and function. Expand abstract.
18289 days ago
4/10 relevant
chemRxiv

Small Molecule-Inducible RNA-Targeting Systems for Temporal Control of RNA Regulation in Vivo

We go on to show the inducible CIRTS editor can be deployed for RNA base editing in vivo, providing a new set of tools to probe RNA regulatory dynamics and control gene expression. Expand abstract.
18289 days ago
5/10 relevant
chemRxiv

Genome-wide meta-analysis, fine-mapping, and integrative prioritization identify new Alzheimer's disease risk genes

We followed this with colocalisation analyses across 109 gene expression quantitative trait loci (eQTL) datasets, and prioritization of genes using protein interaction networks and tissue-specific expression. Expand abstract.
5 hours ago
4/10 relevant
medRxiv

Purine-responsive expression of the Leishmania donovani NT3 purine nucleobase transporter is mediated by a conserved RNA stem-loop

Finally, we provide evidence that the abundance of the trans-acting factor that binds the LdNT3 stem-loop in vivo is substantially higher than required for regulation of LdNT3 alone, implying a potential role in regulating other purine-responsive genes. Expand abstract.
9 hours ago
7/10 relevant
bioRxiv

A mediation analysis of schizophrenia variants: Risk alleles may affect a gene's expression differently from how the expression affects risk

Our results identify specific risk mediating genes and suggest caution in interpreting the biological consequences of targeted modifications of gene expression, as not all eQTL targets may be relevant to disease and those that are might have different than expected directions. Expand abstract.
25 hours ago
10/10 relevant
bioRxiv

TMEM184B controls pruriceptor specification and function

We evaluated DRG gene expression across embryonic and early postnatal development and found that levels of Wnt signaling components are significantly reduced in embryonic DRG from Tmem184b-mutants and restored upon re-expression of Tmem184b. Expand abstract.
1 day ago
5/10 relevant
bioRxiv

Prediction of Discharge Capacity of Labyrinth Weir with Gene Expression Programming

This paper proposes a model based on gene expression programming for predicting discharge coefficient of triangular labyrinth weirs. Expand abstract.
1 day ago
10/10 relevant
Preprints.org

CCSN: Single Cell RNA Sequencing Data Analysis by Conditional Cell-specific Network

A number of scRNA-seq datasets were used to demonstrate the advantages of our approach: (1) one direct association network for one cell; (2) most existing scRNA-seq methods designed for gene expression matrices are also applicable to CCSN-transformed degree matrices; (3) CCSN-based NFE helps resolving the direction... Expand abstract.
1 day ago
4/10 relevant
bioRxiv

Low ribosomal RNA genes copy number provoke genomic instability and chromosomal segment duplication events that modify global gene expression and plant-pathogen response

As a consequence, more than 600 genes were duplicated, often associated with an increase in their expression level. Expand abstract.
2 days ago
10/10 relevant
bioRxiv

AITL: Adversarial Inductive Transfer Learning with input and output space adaptation for pharmacogenomics

AITL takes gene expression of patients and cell lines as the input, employs adversarial domain adaptation and multi-task learning to address these discrepancies, and predicts the drug response as the output. Expand abstract.
3 days ago
4/10 relevant
bioRxiv