Found 1628 results, showing the newest relevant preprints. Sort by relevancy only.Update me on new preprints

Ctcf Haploinsufficiency Mediates Intron Retention in A Tissue-specific Manner

This study provides further evidence for Ctcf dose-dependent and tissue-specific regulation of gene expression and AS. Expand abstract.
2 hours ago
6/10 relevant
bioRxiv

Time-of-day dependent responses of cyanobacterial cellular viability against oxidative stress

The gene expression of ROS scavenging enzymes is regulated by circadian clock genes, which has been considered to help deal with the diurnal photogeneration of reactive oxygen species (ROS). Expand abstract.
6 hours ago
4/10 relevant
bioRxiv

Controlling spatiotemporal pattern formation in a concentration gradient with a synthetic toggle switch

The toggle switch subnetwork, composed of two cross-repressing transcription factors, is a common component of gene regulatory networks in charge of patterning, converting the continuous information provided by the gradient into discrete abutting stripes of gene expression. Expand abstract.
26 hours ago
5/10 relevant
bioRxiv

Linking lysosomal enzyme targeting genes and energy metabolism with altered gray matter volume in children with persistent stuttering

Although the results are correlational and cannot inform us about underlying casual mechanisms, our results suggest a possibility that regions with high expression level of genes associated with stuttering may be particularly vulnerable to the effect of alterations in these genes. Expand abstract.
30 hours ago
7/10 relevant
bioRxiv

Low iron-induced small RNA BrrF regulates central metabolism and oxidative stress responses in Burkholderia cenocepacia

Phenotypic and gene expression analysis of BrrF deletion and overexpression mutants show that the regulation of these genes is BrrF-dependent. Expand abstract.
1 day ago
5/10 relevant
bioRxiv

Quercetin Exerts Anti-Inflammatory Effects via Meanwhile Suppressing TLR2 Gene Expression and STAT3 Protein Phosphorylation in Activated Inflammatory Macrophages

As a result, Q and its metabolite quercetin-3-O-β-D-glucuronide (Q3G) decreased TNF-α gene expression amounts and ratios of pro-/anti-inflammatory (TNF-α/IL-10) cytokine gene expressions, but increased IL-10 gene expression amounts in activated inflammatory macrophages, supporting a... Expand abstract.
2 days ago
10/10 relevant
Preprints.org

Breast tumor stiffness instructs bone metastasis via mechanical memory

Furthermore, we established a mechanical conditioning (MeCo) score comprised of mechanically-regulated genes as a global gene expression measurement of tumor stiffness response. Expand abstract.
2 days ago
4/10 relevant
bioRxiv

BET inhibition disrupts transcription but retains enhancer-promoter contact

Although it is not entirely clear how enhancer-promoter interactions can increase gene expression, this proximity has been observed in multiple systems at multiple loci and is thought to be essential for the maintenance of gene expression. Expand abstract.
2 days ago
5/10 relevant
bioRxiv

Deep sequencing of pre-translational mRNPs reveals hidden flux through evolutionarily conserved AS-NMD pathways

Several of these occur in genes whose overexpression has been linked to poor cancer prognosis. Expand abstract.
3 days ago
4/10 relevant
bioRxiv

Novel meta-analysis pipeline of heterogeneous high-throughput gene expression datasets reveals dysregulated interactions and pathways in asthma

As a meta-analysis, we apply a mixed-model effect size test to determine differentially expressed (DE) genes across all three studies. Expand abstract.
3 days ago
10/10 relevant
medRxiv