Found 196 results, showing the newest relevant preprints. Sort by relevancy only.Update me on new preprints

Functional angiogenesis requires microenvironmental cues balancing endothelial cell migration and proliferation

To investigate how microenvironmental cues regulate angiogenesis and the function of resulting microvasculature, we multiplexed an established angiogenesis-on-a-chip platform that affords higher throughput investigation of 3D endothelial cell sprouting emanating from a parent vessel through defined biochemical gradients and extracellular... Expand abstract.
4 days ago
4/10 relevant
bioRxiv

Structural analysis of nonapeptides derived from elastin

Elastin-derived peptides are released from the extracellular matrix remodeling by numerous proteases and seem to regulate many biological processes, notably cancer progression. Expand abstract.
5 days ago
4/10 relevant
bioRxiv

Mitral valve leaflet response to ischemic mitral regurgitation: From gene expression to tissue remodeling

RNA sequencing provided a baseline for global gene expression changes in response to myocardial infarction with and without ischemic mitral regurgitation and suggests YAP-induced mechanotransduction, altered expression of extracellular matrix-related genes, and recruitment of immune cells as mechanisms contributing... Expand abstract.
6 days ago
5/10 relevant
bioRxiv

A FIJI Macro for quantifying pattern in extracellular matrix

Here we present an overview of the pipeline and demonstrate its utility for quantifying extracellular matrix patterns in both experimental and clinical samples. Expand abstract.
6 days ago
10/10 relevant
bioRxiv

Proteoglycan IMPG2 shapes the interphotoreceptor matrix and modulates vision

In conclusion, our results demonstrate the role of IMPG2 in shaping the IPM, shed light on the potential mechanisms leading to subretinal lesions and show that the secreted proteoglycans depend on the extracellular matrix environment to properly integrate into the matrix. Expand abstract.
14 days ago
7/10 relevant
bioRxiv

Targeting DDR1 and DDR2 overcomes matrix-mediated melanoma cell adaptation to BRAF-targeted therapy

Microenvironment components including the extracellular matrix (ECM) can support tumor cell adaptation and tolerance to targeted therapies, however the underlying mechanisms remain poorly understood. Expand abstract.
14 days ago
5/10 relevant
bioRxiv

Semaphorin 3A binding to chondroitin sulfate E enhances the biological activity of the protein, and cross-links and rigidifies glycosaminoglycan matrices

The results suggest that Sema3A can rigidify and cross-link GAG matrices, implicating Sema3A could function as an extracellular matrix organizer in addition to binding to and signaling through its cognate cell surface receptors. Expand abstract.
22 days ago
4/10 relevant
bioRxiv

Three-dimensional traction microscopy accounting for cell-induced matrix degradation

Tractions exerted by cells on the extracellular matrix (ECM) are critical in many important physiological and pathological processes such as embryonic morphogenesis, wound healing, and cancer metastasis. Expand abstract.
27 days ago
4/10 relevant
bioRxiv

Meso-scale multi-material fabrication of a Synthetic ECM Mimic for In vivo-like Peripheral Nerve Regeneration

Here, we describe the synthetic recreation of the highly ordered extracellular matrix (ECM) of the peripheral nervous system (PNS) in terms of structure and scale, providing a versatile 3D culturing platform that achieves some of the highest in vitro neurite growth rates so far reported. Expand abstract.
28 days ago
4/10 relevant
bioRxiv

Fibrotic human lung extracellular matrix as a disease-specific substrate for 3D in-vitro models of pulmonary fibrosis

Here we report the development and characterization of a human pulmonary fibrosis-specific cell culture substrate comprised of intact fibrotic lung extracellular matrix that recapitulates the human IPF disease environment in vitro. Expand abstract.
35 days ago
10/10 relevant
bioRxiv