Found 1130 results, showing the newest relevant preprints. Sort by relevancy only.Update me on new preprints

The Min system disassembles FtsZ foci and inhibits polar peptidoglycan remodeling in Bacillus subtilis

Whereas the parameters of FtsZ dynamics change in the minD mutant, the overall cell cycle remains the same, albeit with elongated cells necessary to accumulate a threshold concentration of FtsZ for promoting medial division. Expand abstract.
28 hours ago
5/10 relevant
bioRxiv

Nuclear Export of Cyclin B Mediated by the Nup62 Complex is Required for Meiotic Initiation in Drosophila Males

Results: The cell cycle of the Nup62-depleted cells was arrested before meiosis without CDK1 activation. Expand abstract.
1 day ago
7/10 relevant
Preprints.org

Rif1 functions in a tissue-specific manner to control replication timing through its PP1-binding motif

Our results demonstrate that cell lineage has the largest effect on RT, whereas switching from a mitotic to an endoreplicative cell cycle has little to no effect on RT. Expand abstract.
4 days ago
4/10 relevant
bioRxiv

Loss of Aurora kinase signaling allows lung cancer cells to adopt an alternative cell cycle and resist anti-mitotic drugs

These cancer persister cells can re-enter the proliferative cell cycle when anti-mitotic treatment is terminated. Expand abstract.
9 days ago
10/10 relevant
bioRxiv

The apparent requirement for protein synthesis during G2 phase is due to checkpoint activation

Protein synthesis inhibitors (e.g. cycloheximide) prevent cells from entering mitosis, suggesting that cell cycle progression requires protein synthesis until right before mitotic entry. Expand abstract.
10 days ago
4/10 relevant
bioRxiv

A male infertility mutation reverts NANOS1 activity from anti-apoptotic to pro-apoptotic by disrupting repression of GADD45A, GADD45B, GADD45G and RHOB genes

Conclusions: This report underscores the conservation of Nanos from flies to humans as a repressor of pro-apoptotic mRNAs in germ cells, and provides a basis for understanding NANOS1 functions in human reproductive health. Expand abstract.
15 days ago
4/10 relevant
bioRxiv

FLIP(L) determines p53 induced life or death

Notably, FLIP(L) depletion inhibits p53-induced expression of the cell cycle regulator p21 and enhances p53-mediated upregulation of PUMA, with the latter activating mitochondrial-mediated apoptosis in FLIP(L)-depleted, Nutlin-3A-treated cells lacking TRAIL-R2/caspase-8. Expand abstract.
15 days ago
7/10 relevant
bioRxiv

RADA is the main branch migration factor in plant mitochondrial recombination and its defect leads to mtDNA instability and cell cycle arrest

Rather, it seems that it is the activation of genes that repress cell cycle progression that is partially the cause of the stunted growth of radA mutants. Expand abstract.
17 days ago
10/10 relevant
bioRxiv

Loss of histone H3.3 results in DNA replication defects and altered origin dynamics in C. elegans

These replication defects are accompanied by replication checkpoint activation, a prolonged cell cycle, and increased lethality in checkpoint-compromised embryos. Expand abstract.
17 days ago
4/10 relevant
bioRxiv

Saringosterol Acetate from a Popular Edible Seaweed, Hizikia Fusiformis Attenuated Proliferation of Human Lung Adenocarcinoma Epithelial Cells (A549 Cells) via Apoptosis Signaling Pathway

In conclusion, we suggested that SA induces apoptosis against A549 cells via Bid and caspase 8 dependent pathway. Expand abstract.
23 days ago
5/10 relevant
Preprints.org